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Histofreezer

Portable Cryosurgical System

The Histofreezer® Portable Cryosurgical System is a professional-grade product that offers medical professionals an easy and effective method to treat nine different types of skin lesions, including common, plantar and genital warts and other common benign skin lesions. More than 60,000 medical professionals in primary care, internal medicine, podiatry, ob/gyn and dermatology areas of care have either added Histofreezer to their practice offering or replaced more invasive and less tolerated procedures with the Histofreezer advantage.

Histofreezer Canister

How to Use

Histofreezer is user-friendly and requires just one hand to perform the procedure. It's as easy as 1 - 2 - 3.

Step 1 Charge

Charge

Charge the applicator by pressing the valve
until droplets start to form.

Step 2 Invert

Invert

Invert the canister for 15 seconds
to achieve optimal freezing temperature.

Step 3 Apply

Apply

Apply the frozen applicator to lesion
for 15-40 seconds*
*See package insert for indications treatment time

Product Information

Clinical Indications

Clinical Indications

Performance

Treatment Times

Treatment Times

Product Brochure

Safety Data Sheets

Practice Support

International Distributors

For informational purposes. Contact the appropriate distributor for product inquiries/orders/availability in your territory.

If you are a current Histofreezer distributor and would like your information listed on our website, please contact us at customercare@orasure.com.

If your supplier is not listed, please contact OraSure Customer Care.

Outside U.S.:

(001) 610-882-1820

Fax:

(001) 610-882-3572

FAQs

The following are frequently asked questions about the Histofreezer Portable Cryosurgical System from OraSure Technologies, Inc., a product only available to the professional market. For additional information, please contact Customer Care.

The Histofreezer products are only sold through Medical/Surgical distributors. Please refer to the International Distributor list above and contact the authorized distributor in your area.

H-30M Convenience Kit

Histofreezer H-30M Convenience Kit
  • 30-60 applications per kit*
  • (16) 2mm and (16) 5mm applicators
  • Up to three-year shelf-life
  • Ideal for both small and large lesions, perfect for every treatment room.

H-60 Economy Kit

Histofreezer H-60 Economy Kit
  • 60-120 applications per kit*
  • (24) 2mm and (36) 5mm applicators
  • Up to three-year shelf-life
  • Ideal for both small and large lesions

H-505 5mm Specialty Kit

Histofreezer H-505 5mm Specialty Kit
  • 50-100 applications per kit*
  • (52) 5mm applicators
  • Up to three-year shelf-life
  • Ideal for treatment of larger lesions

H-602 2mm Specialty Kit

Histofreezer H-602 2mm Specialty Kit
  • 60-120 applications per kit*
  • (60) 2mm applicators
  • Up to three-year shelf-life
  • Ideal for treatment of smaller lesions


*See Package Insert for more information

Verruca vulgaris (Common warts)
A common wart of the skin or mucosa. The warts are round firm skin-colored papules with a hyperkeratotic (thickening) papillary surface. Sizes range between 1 to 10 mm. The hands, fingers and knees are common sites. Thrombosed capillaries which appear as black dots can be seen on the surface of some warts.
Verruca plantaris (Plantar warts)
Painful, unappealing benign tumors on the sole of the feet caused by the Human Papillomavirus (HPV-1) when it enters the skin through a cut or skin erosion. These warts can generally be characterized as rough, round-oval growths that can be lighter or darker than their surroundings.
Verruca plana
Also known as a "flat wart", round or oval shaped, only slightly elevated and sharply defined. They may induce however significant disturbances of pigmentation anywhere from flesh-colored in appearance to dark brown. Auto inoculation by scratching can result in linearly grouped lesions. Location of these lesions is commonly found on the forehead, cheeks, perioral (tissues around the mouth) as well as the dorsal side of hands and arms.
Molluscum contagiosum
A contagious disease of the skin caused by intranuclear proliferation of a virus of the family Poxviridae and characterized by the appearance of small,pearly, umbilicated papular epidermal growths. In adults it typically occurs on or near the genitals and is sexually transmitted.
Acrochordon
Common benign skin growths (a/k/a skin tags) that occur most often after midlife. They are tiny skin protrusions, and may have a small narrow stalk connecting the skin bump to the surface of the skin. The origin is unknown however is believed to be an inherited indication.
Actinic keratosis
A premalignant warty lesion occurring on the sun-exposed skin of the face or hands in aged light-skinned persons; hyperkeratosis may form a cutaneous horn, and squamous cell carcinoma of low-grade malignancy may develop in a small proportion of untreated patients.
Lentigo
A brown macule resembling a freckle except that the border is usually regular, and microscopic proliferation of rete ridges is present; scattered melanocytes are seen in the basal cell layer.
Seborrheic keratosis
Superficial, benign, verrucous, often pigmented, greasy lesions consisting of proliferating epidermal cells, resembling basal cells,enclosing horn cysts; they usually occur after the third decade.
Condyloma acuminata
A warty growth on the external genitals or at the anus, consisting of fibrous overgrowths covered by thickened epithelium showing koilocytosis,due to sexually transmitted infection with human papilloma virus; malignant change is associated with particular types of the virus.

Note: Refer to the Histofreezer Package Inserts under the "HOW TO USE” section above.

Lesions are resolved in one to four treatments with two-week intervals between treatments.
The Histofreezer products have a shelf life of three years from the date of manufacture. Though the need is unlikely, this means there is sufficient cryogen in each canister on the expiration date to saturate all of the Histofreezer applicators provided in a kit.
A study showed an average rate of 93.4% effectiveness for a variety of lesions (see Histofreezer versus Liquid Nitrogen study under the Performance section).

After saturation of a 5mm Histofreezer applicator, you may perform a second application on the same patient after a 15-second pause between applications. The use time of a saturated 5mm Histofreezer applicator is 120 seconds.

After saturation of a 2mm Histofreezer applicator, you may perform a second application on the same patient after a 15-second pause between applications.The use time of a saturated 2mm Histofreezer applicator is 90 seconds.

Note: Refer to the Histofreezer Package Inserts under the "HOW TO USE” section above.

Hold the canister in the upright position. Charge the bud until droplets form. Stop charging, invert the canister with the bud pointing to the floor and wait 15 seconds before treating the lesion.

Click Here to View Histofreezer Demonstration Video
The applicator temperature reaches -55°C, which minimizes risk of scarring or blistering of the treatment site.
Do not use a used applicator for another patient due to risk of cross-contamination. A sufficient supply of applicators is included with each kit.
No. Histofreezer has been approved for external condyloma lesions only. This would include any condyloma for anogenital, labial and penile lesions.
The Dimethyl Ether, Propane, and Isobutane gas in the Histofreezer canister is a clear liquefied gas that is not harmful to clothing or furniture. Any drips that occur can be simply washed off with a mild soap and will not leave any stains.

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